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US 6,485,718 B1Granted
Site specific ligation of proteins to synthetic particles
AssigneePharmacia Corporation
InventorsRajani V. Parthasarathy, Stephen C. Lee
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Abstract
The present invention relates to site-specific conjugation of synthetic particles to proteins.
Claims1
A method for site specifically attaching a synthetic particle to the N-terminus of a protein, said method comprising the steps of:
- a) converting a polypeptide containing a serine as its N-terminal amino acid to an aldehyde;
- b) converting the amine of a synthetic particle to a oxiamine;
- and
- c) combining said aldehyde polypeptide containing a serine as its N-terminal amino acid to said synthetic particle at said oxiamine.
1 more element
Dependencies are inferred from the claim text.