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AssigneeEuropean Community (EC)
InventorsLothar Koch, Christos Apostolidis, Roger Molinet, Bruno Brandalise, Willem Janssens, Jacques Van Geel
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This invention relates to a method and an apparatus for preparing Bi-213 to be integrated in a radioimmunocojugate for human therapeutic use. According to the invention the method comprises the sequence of steps as follows: a) an ampoule 5 containing colloid-free actinium-225, obtained from drying an actinium nitrate solution, is loaded into a container 20 provided with radiation panels 21; b) a dissolving medium is poured into the ampoule 5; c) the solution obtained in the ampoule is transferred into an ion exchange column 6; d) an elution medium is circulated through the column 6; e) the eluate containing eluted Bi-213 is pumped towards a vial 10 for quantification and quality control.
A method for preparing Bi-213 to be integrated in a radioimmunoconjugate for human therapeutic use, comprising a sequence of steps as follows:
An apparatus for preparing Bi-213 to be integrated in a radioimmunoconjugate for human therapeutic use, comprising a container, protected by radiation shielding panels, a first volume of said container intended to receive a transport ampoule and a second volume of said container intended to receive an ion exchange column are arranged in serial communication, said container mounted on a tilt frame allowing tilting of the container from a first, horizontal position for dissolution in which the first volume is located next to the second volume, into a second, vertical position in which said transport ampoule is above said ion exchange column for elution, a circulation duct including a circulating pump, provided to connect the ends of the two volumes which are remote from their interconnection channel, supply bottles containing a dissolving medium and an elution medium being connected via a valve to a transport ampoule and, data processing means provided to automatically control a tilt mechanism, valves and pumps and a GeLi well counter.
Dependencies are inferred from the claim text.