Multiple fluid sample processor and system

A fluid sample processing apparatus comprising:

• a reservoir plate member;
• a distribution plate member connected to said reservoir plate member;
• and
• a well plate member connected to said distribution plate member;
• said reservoir plate member having an upper surface and a lower surface and a first plurality of orifices in the upper surface for entry of liquids therein, and a plurality of second orifices on the lower surface for exhausting of liquids from said reservoir plate member, said first plurality of orifices being spatially oriented in across said first surface, said second plurality of orifices fluidically coupled to said first orifices, said second plurality of orifices arranged in a rectangular pattern directly adjacent to edges of said reservoir plate member;
• a first plurality of micro-sized channels in said reservoir plate member for conveying liquids from said first plurality of orifices to said plurality of second orifices;
• said distribution plate member having an upper surface and a lower surface and a plurality of layers and a plurality of third orifices in said upper surface of said distribution plate member, said third orifices being spatially arranged in a rectilinear pattern in alignment with said second plurality of orifices in said reservoir plate member in order to transfer liquids from said reservoir plate member to said distribution plate member, the rectangular pattern having a first pair of opposites sides and a second pair of opposite side, said first pair of opposite sides have corresponding with row inputs of said distribution plate, and said second pair of opposite sides corresponding with column inputs of said distribution plate;
• a second plurality of micro-sized channels in said distribution plate member for fluid communication between the rectilinear array of orifices on the upper surface of distribution plate member and a plurality of fourth orifices on the lower surface of said distribution layer;
• said well plate member having a plurality of well members therein, said well members having first openings in alignment with said plurality of fourth orifices in the lowermost layer of said distribution plate member.

A fluid sample processing apparatus comprising:

• a reservoir plate member;
• a distribution plate member connected to said reservoir plate member;
• and
• a well plate member connected to said distribution plate member;
• said reservoir plate member having an upper surface and a lower surface and a first plurality of orifices in the upper surface for entry of liquids therein, and a plurality of second orifices on the lower surface for exhausting of liquids from said reservoir plate member, said first and second plurality of orifices being spatially oriented;
• a first plurality of micro-sized channels in said reservoir plate member for conveying liquids from said first plurality of orifices to said plurality of second orifices;
• said distribution plate member having an upper surface and a lower surface and a plurality of third orifices in said upper surface of said distribution plate member, said third orifices being spatially arranged in alignment with said second plurality of orifices in said reservoir plate member in order to transfer liquids from said reservoir plate member to said distribution plate member;
• a second plurality of micro-sized channels in said distribution plate member for fluid communication between the orifices on the upper surface of the distribution plate member and a plurality of fourth orifices on the lower surface of said distribution layer;
• said well plate member having a plurality of well members therein for conducting chemical and biological events, said well members having first openings in alignment with said plurality of fourth orifices of said distribution plate member;
• and
• a vacuum box mechanism for connected to said fluid sample processing apparatus for vacuum exhaustion of materials from said well plate member.

A fluid sample processing apparatus comprising:

• a reservoir plate member;
• a distribution plate member connected to said reservoir plate member;
• and
• a well plate member connected to said distribution plate member;
• said reservoir plate member having an upper surface and a lower surface and a first plurality of orifices in the upper surface for entry of liquids therein, and a plurality of second orifices on the lower surface for exhausting of liquids from said reservoir plate member, said first and second plurality of orifices being spatially oriented;
• a first plurality of micro-sized channels in said reservoir plate member for conveying liquids from said first plurality of orifices to said plurality of second orifices;
• said distribution plate member having an upper surface and a lower surface and a plurality of third orifices in said upper surface of said distribution plate member, said third orifices being spatially arranged in alignment with said second plurality of orifices in said reservoir plate member in order to transfer liquids from said reservoir plate member to said distribution plate member;
• a second plurality of micro-sized channels in said distribution plate member for fluid communication between the orifices on the upper surface of the distribution plate member and a plurality of fourth orifices on the lower surface of said distribution layer;
• said well plate member having a plurality of well members therein for conducting chemical and biological events, said well members having first openings in alignment with said plurality of fourth orifices of said distribution plate member;
• and
• electrical spray means for exhaustion of liquid materials from said well members.

A fluid sample processing apparatus comprising:

• a reservoir plate member;
• a distribution plate member connected to said reservoir plate member;
• and
• a well plate member connected to said distribution plate member;
• said reservoir plate member having an upper surface and a lower surface and a first plurality of orifices in the upper surface for entry of liquids therein, and a plurality of second orifices on the lower surface for exhausting of liquids from said reservoir plate member, said first and second plurality of orifices being spatially oriented;
• a first plurality of micro-sized channels in said reservoir plate member for conveying liquids from said first plurality of orifices to said plurality of second orifices;
• said distribution plate member having an upper surface and a lower surface and a plurality of third orifices in said upper surface of said distribution plate member, said third orifices being spatially arranged in alignment with said second plurality of orifices in said reservoir plate member in order to transfer liquids from said reservoir plate member to said distribution plate member;
• a second plurality of micro-sized channels in said distribution plate member for fluid communication between the orifices on the upper surface of the distribution plate member and a plurality of fourth orifices on the lower surface of said distribution layer;
• said well plate member having a plurality of well members therein for conducting chemical and biological events, said well members having first openings in alignment with said plurality of fourth orifices of said distribution plate member;
• and
• micro-sized valve means in said plurality of first openings in said well plate member.

A fluid sample processing apparatus comprising:

• a reservoir plate member;
• a distribution plate member connected to said reservoir plate member;
• and
• a well plate member connected to said distribution plate member;
• said reservoir plate member having an upper surface and a lower surface and a first plurality of orifices in the upper surface for entry of liquids therein, and a plurality of second orifices on the lower surface for exhausting of liquids from said reservoir plate member, said first and second plurality of orifices being spatially oriented;
• a first plurality of micro-sized channels in said reservoir plate member for conveying liquids from said first plurality of orifices to said plurality of second orifices;
• said distribution plate member having an upper surface and a lower surface and a plurality of third orifices in said upper surface of said distribution plate member, said third orifices being spatially arranged in alignment with said second plurality of orifices in said reservoir plate member in order to transfer liquids from said reservoir plate member to said distribution plate member;
• a second plurality of micro-sized channels in said distribution plate member for fluid communication between the orifices on the upper surface of the distribution plate member and a plurality of fourth orifices on the lower surface of said distribution layer;
• said well plate member having a plurality of well members therein for conducting chemical and biological events, said well members having first openings in alignment with said plurality of fourth orifices of said distribution plate member wherein said well members have second openings therein for exhaustion of materials from said well members, said second openings in said well members comprise a plurality of micro-sized valves.

A fluid sample processing apparatus comprising:

• a reservoir plate member;
• a distribution plate member connected to said reservoir plate member;
• and
• a well plate member connected to said distribution plate member;
• said reservoir plate member having an upper surface and a lower surface and a first plurality of orifices in the upper surface for entry of liquids therein, and a plurality of second orifices on the lower surface for exhausting of liquids from said reservoir plate member, said first and second plurality of orifices being spatially oriented;
• a first plurality of micro-sized channels in said reservoir plate member for conveying liquids from said first plurality of orifices to said plurality of second orifices;
• said distribution plate member having an upper surface and a lower surface and a plurality of third orifices in said upper surface of said distribution plate member, said third orifices being spatially arranged in alignment with said second plurality of orifices in said reservoir plate member in order to transfer liquids from said reservoir plate member to said distribution plate member;
• a second plurality of micro-sized channels in said distribution plate member for fluid communication between the orifices on the upper surface of the distribution plate member and a plurality of fourth orifices on the lower surface of said distribution layer;
• said well plate member having a plurality of well members therein for conducting chemical and biological events, said well members having first openings in alignment with said plurality of fourth orifices of said distribution plate member;
• and
• a first sealing member positioned between said distribution plate member and said well plate member, said sealing member is an elastomeric member having a first plurality of openings positioned in alignment with said plurality of fourth orifices on said distribution plate member and a second plurality of openings positioned between said first plurality of openings, wherein when said sealing member is altered in cross-section, said elastomeric material can flow into said second openings.

A fluid sample processing apparatus comprising:

• a reservoir plate member;
• a distribution plate member connected to said reservoir plate member;
• and
• a well plate member connected to said distribution plate member;
• said reservoir plate member having an upper surface and a lower surface and a first plurality of orifices in the upper surface for entry of liquids therein, and a plurality of second orifices on the lower surface for exhausting of liquids from said reservoir plate member, said first and second plurality of orifices being spatially oriented;
• a first plurality of micro-sized channels in said reservoir plate member for conveying liquids from said first plurality of orifices to said plurality of second orifices;
• said distribution plate member having an upper surface and a lower surface and a plurality of third orifices in said upper surface of said distribution plate member, said third orifices being spatially arranged in alignment with said second plurality of orifices in said reservoir plate member in order to transfer liquids from said reservoir plate member to said distribution plate member;
• a second plurality of micro-sized channels in said distribution plate member for fluid communication between the orifices on the upper surface of the distribution plate member and a plurality of fourth orifices on the lower surface of said distribution layer;
• said well plate member having a plurality of well members therein for conducting chemical and biological events, said well members having first openings in alignment with said plurality of fourth orifices of said distribution plate member;
• wherein said plurality of first orifices in said reservoir plate member comprises 384 orifices and said apparatus further comprises a second reservoir member attached to said reservoir plate member, said second reservoir member having 96 orifices on its upper surface and a plurality of fan-out channels therein communicating said 96 orifices to said 384 orifices on said reservoir plate member.

A fluid sample processing apparatus comprising:

• a reservoir plate member;
• a distribution plate member connected to said reservoir plate member;
• and
• a well plate member connected to said distribution plate member;
• said reservoir plate member having an upper surface and a lower surface and a first plurality of orifices in the upper surface for entry of liquids therein, and a plurality of second orifices on the lower surface for exhausting of liquids from said reservoir plate member, said first and second plurality of orifices being spatially oriented;
• a first plurality of micro-sized channels in said reservoir plate member for conveying liquids from said first plurality of orifices to said plurality of second orifices;
• said distribution plate member having an upper surface and a lower surface and a plurality of third orifices in said upper surface of said distribution plate member, said third orifices being spatially arranged in alignment with said second plurality of orifices in said reservoir plate member in order to transfer liquids from said reservoir plate member to said distribution plate member;
• a second plurality of micro-sized channels in said distribution plate member for fluid communication between the orifices on the upper surface of the distribution plate member and a plurality of fourth orifices on the lower surface of said distribution layer;
• said well plate member having a plurality of well members therein for conducting chemical and biological events, said well members having first openings in alignment with said plurality of fourth orifices of said distribution plate member;
• wherein said plurality of first orifices in said reservoir plate member comprises 1536 orifices and said apparatus further comprises a second reservoir member attached to said reservoir plate member, said second reservoir member having 96 orifices on its upper surface and a plurality of fan-out channels therein communicating said 96 orifices to said 1536 orifices on said reservoir plate member.

A fluid sample processing apparatus comprising:

• a reservoir plate member;
• a distribution plate member connected to said reservoir plate member;
• and
• a well plate member connected to said distribution plate member;
• said reservoir plate member having an upper surface and a lower surface and a first plurality of orifices in the upper surface for entry of liquids therein, and a plurality of second orifices on the lower surface for exhausting of liquids from said reservoir plate member, said first and second plurality of orifices being spatially oriented;
• a first plurality of micro-sized channels in said reservoir plate member for conveying liquids from said first plurality of orifices to said plurality of second orifices;
• said distribution plate member having an upper surface and a lower surface and a plurality of third orifices in said upper surface of said distribution plate member, said third orifices being spatially arranged in alignment with said second plurality of orifices in said reservoir plate member in order to transfer liquids from said reservoir plate member to said distribution plate member;
• a second plurality of micro-sized channels in said distribution plate member for fluid communication between the orifices on the upper surface of the distribution plate member and a plurality of fourth orifices on the lower surface of said distribution layer;
• said well plate member having a plurality of well members therein for conducting chemical and biological events, said well members having first openings in alignment with said plurality of fourth orifices of said distribution plate member;
• a plurality of magnets positioned adjacent to said well plate member for attracting magnetic particles in said well members.

A fluid sample processing apparatus comprising:

• a reservoir plate member;
• a distribution plate member connected to said reservoir plate member;
• and
• a well plate member connected to said distribution plate member;
• said reservoir plate member having an upper surface and a lower surface and a first plurality of orifices in the upper surface for entry of liquids therein, and a plurality of second orifices on the lower surface for exhausting of liquids from said reservoir plate member, said first and second plurality of orifices being spatially oriented;
• a first plurality of micro-sized channels in said reservoir plate member for conveying liquids from said first plurality of orifices to said plurality of second orifices;
• said distribution plate member having an upper surface and a lower surface and a plurality of third orifices in said upper surface of said distribution plate member, said third orifices being spatially arranged in alignment with said second plurality of orifices in said reservoir plate member in order to transfer liquids from said reservoir plate member to said distribution plate member;
• a second plurality of micro-sized channels in said distribution plate member for fluid communication between the orifices on the upper surface of the distribution plate member and a plurality of fourth orifices on the lower surface of said distribution layer;
• said well plate member having a plurality of well members therein for conducting chemical and biological events, said well members having first openings in alignment with said plurality of fourth orifices of said distribution plate member;
• and
• a non-fluidic plate member having a plurality of light emitting detection elements therein.