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US 6,485,514 B1Granted
Local delivery of therapeutic agents
AssigneeSuperGen, Inc.
InventorSimeon M. Wrenn, Jr.
Life of this patent
Estimating the term…
Abstract
Disclosed are implants, stents, catheters, methods and kits for the local delivery of therapeutic agents that are preferentially cytotoxic or cytostatic with regards to proliferating cells to sites where proliferative cells are present.
Claims5
A method for treating restenosis of a blood vessel by using a water-insoluble camptothecin compound in combination with a stent to treat tissue of the blood vessel, the method comprising:
- coating a stent with a water-insoluble camptothecin compound dispersed in 1% poly(L-lactic acid) solution in chloroform
- inserting the stent into a blood vessel;
- supporting the blood vessel with the stent to mechanically prevent the collapse and reocclusion of the blood vessel;
- and
- contacting tissue forming the blood vessel with the water-insoluble camptothecin compound,
- wherein the water-insoluble camptothecin compound is selected from the group consisting of 9-nitro-20(S)-camptothecin and 9-amino-20(S) camptothecin in a concentration sufficient to reduce restenosis In the blood vessel.
3 more elements
Dependencies are inferred from the claim text.