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US 6,482,986 B1Granted
Benzene derivatives, preparation method and pharmaceutical compositions containing same
AssigneeSanofi-Synthelabo
InventorsRobert Boigegrain, Bernard Bourrie, Martine Bourrie, Pierre Casellas, Jean Marc Herbert, Pierre Lair, Dino Nisato, Raymond Paul, Jean Claude Vernieres
Life of this patent
Estimating the term…
Abstract
The invention concerns compounds of formula (I) wherein A, X, Y, n, R1, R2 and R3 are as defined in claim 1. Said compounds are specifically binding to sigma receptors particularly those of the peripheral nervous system.
Claims15
A compound of formula:
- in which:
- A represents a group chosen from the following:
- —C≡C—, —CH═CH—;
- —CH2—CH2—
- n is equal to 1 or 2;
- X represents a hydrogen, chlorine or fluorine atom or a methyl or methoxy group;
- Y represents a hydrogen atom or a chlorine or fluorine atom;
- R1 represents a cyclohexyl group monosubstituted, disubstituted, trisubstituted or tetrasubstituted with a methyl group;
- a phenyl group monosubstituted or disubstituted with a fluorine or chlorine atom or with a methoxy group;
- a cycloheptyl, tert-butyl, dicyclopropylmethyl, bicyclo[3.2.1]octanyl, 4-tetrahydropyranyl, 4-tetrahydrothiopyranyl or 1- or 2-adamantyl or adamantan-2-ol group;
- or R1 represents a phenyl group, it being understood that, in this case, X and Y are other than hydrogen;
- R2 represents a hydrogen atom or a (C1-C4)alkyl group optionally substituted with a trifluoromethyl group;
- R3 represents a (C5-C7)cycloalkyl;
- and the addition salts of these compounds with pharmaceutically acceptable acids, as well as the solvates and hydrates thereof.
11 more elements
Dependencies are inferred from the claim text.