US 6,482,861 B2Granted

Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer

AssigneeThe University of Tennessee Research Corporation

InventorsDuane D. Miller, Leonid I. Kirkovsky, James T. Dalton, Arnab Mukherjee

Life of this patent

Estimating the term…

Abstract

The present invention relates to an antiandrogen compound and a method of treating prostate cancer in a patient utilizing the compound. The present invention also relates to a pharmaceutical composition which includes the compound.

Claims5

Dependent claims

A method of irreversibly binding a compound to an androgen receptor of a mammal, comprising the step of contacting a compound of formula I to an

androgen receptor of a mammal under conditions effective to irreversibly bind said compound to said androgen receptor;
wherein
Z is NCS or CN,
R is NH2, NCS, N3 or NHCOCH2Y,
X is S or SO2, and
Y is a halogen, or
wherein
Z is NCS,
R is F, and
X is S or SO2.

7 more elements

Dependencies are inferred from the claim text.

Facts

Application: 09/510,108Filed 22 Feb 2000 · continuation
Priority: 27 Nov 1996
Published: US 2001/0012839 A19 Aug 2001
Granted: 19 Nov 2002
Term ends: Not estimatedThe source records don’t support an estimate.

Classification6 codes

C07C 331/08
Thiocyanates: having sulfur atoms of thiocyanate groups bound to carbon atoms of six-membered aromatic rings
A61K 31/165
Amides, e.g. hydroxamic acids: having aromatic rings, e.g. colchicine, atenolol, progabide
C07C 317/46
Having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton: the carbon skeleton being further substituted by…
C07C 323/60
Having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton: with the carbon atom of at least one of the…

Family

Application60/031,861Us provisional application · filed 27 Nov 1996
Application08/978,511Parent of this continuation · filed 25 Nov 1997
US 2001/0012839 A1Pre-grant publication · published 9 Aug 2001
US 6,071,957 AParent of this continuation
US 6,482,861 B2This patent

From the US filing history. Foreign family members aren’t listed.

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Citations

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Abstract

Facts

Application

09/510,108Filed 22 Feb 2000 · continuation

Priority

27 Nov 1996

Published

US 2001/0012839 A19 Aug 2001

Granted

19 Nov 2002

Term ends

Not estimatedThe source records don’t support an estimate.

Classification6 codes

C07C 331/08
Thiocyanates: having sulfur atoms of thiocyanate groups bound to carbon atoms of six-membered aromatic rings
A61K 31/165
Amides, e.g. hydroxamic acids: having aromatic rings, e.g. colchicine, atenolol, progabide
C07C 317/46
Having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton: the carbon skeleton being further substituted by…
C07C 323/60
Having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton: with the carbon atom of at least one of the…

Family

Application60/031,861Us provisional application · filed 27 Nov 1996

Application08/978,511Parent of this continuation · filed 25 Nov 1997

US 2001/0012839 A1Pre-grant publication · published 9 Aug 2001

US 6,071,957 AParent of this continuation

US 6,482,861 B2This patent

From the US filing history. Foreign family members aren’t listed.