Method for inhibiting interleukin-2 production using tricyclo compounds
AssigneeFujisawa Pharmaceutical Co., Ltd.
InventorsMasakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka
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Abstract
This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
Claims3
A method for inhibiting interleukin -2 (IL-2) production by administering to a subject in need thereof an amount of a compound of formula (I) effective to inhibit the production of IL-2:
- wherein
- R1 is hydroxy or pharmaceutically acceptable protected hydroxy selected from the group consisting of 1-(lower alkylthio)(lower)alkyloxy, tri(lower)alkylsilyloxy, lower alkyl-diphenyl-silyloxy, pharmaceutically acceptable organic carboxylic acyloxy, pharmaceutically acceptable organic sulfonic acyloxy, and pharmaceutically acceptable organic carbamic acyloxy,
- R2 is hydrogen or the same meanings as R1,
- R3 is methyl, ethyl, propyl or allyl, n is an integer of 1 or 2, and the symbol of a line and dotted line is a single bond or a double bond, or pharmaceutically acceptable basic salt thereof.
Dependencies are inferred from the claim text.