Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases

A compound of formula I

• wherein
• X is L1OH or L2Z2;
• L1 is (CR3aR3b)r or (CR3aR3b)m—Z3—(CR3′aR3′b)n;
• L2 is (CR3aR3b)p—Z4—-(CR3′aR3′b)q or ethenyl;
• Z1 is CH;
• Z2 is optionally substituted hydroxycycloalkyl, optionally substituted hydroxycycloalkenyl, optionally substituted hydroxyheterocycyl or optionally substituted hydroxyheterocyclenyl;
• Z3 is O, NR4, S, SO or SO2;
• Z4 is O, NR4, S, SO, SO2 or a bond;
• m is 0 or 1;
• n is 2 or 3, and n+m=2or 3;
• p and q are independently 0,1,2,3 or 4, and p+q=0,1,2,3 or 4 when Z4 is a bond, and p+q=0,1,2 or 3 when Z4 is other than a bond;
• r is 2,3 or 4;
• R1aand R1b are independently optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, hydroxy, acyloxy, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted heterocyclyloxy, optionally substituted heterocyclylcarbonyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, cyano, R5R6N or acylR5N, or one of R1a and R1b is hydrogen or halo and the other is optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, hydroxy, acyloxy, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted heterocyclyloxy, optionally substituted heterocyclylcarbonyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, cyano, R5R6N or acylR5N.
• R1c is hydrogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, hydroxy, acyloxy, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted heterocyclyloxy, optionally substituted heterocyclylcarbonyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, halo, cyano, R5R6N or acylR5N;
• R3a, R3b, R3′b are independently hydrogen or alkyl;
• R4 is hydrogen, alkyl or acyl;
• and
• R5 and R6 are independently hydrogen or alkyl, or R5 and R6 taken together with the nitrogen atom to which R5 and R6 are attached from azaheterocyclyl, or
• an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.