Use of neomycin for treating angiogenesis-related diseases
AssigneeThe Endowment for Research in Human Biology, Inc.
InventorsGuo-fu Hu, Bert L. Vallee
Life of this patent
Estimating the term…
Abstract
The present invention is directed to using neomycin or an analogue thereof as an therapeutic agent to treat angiogenesis-related diseases, which are characterized by excessive, undesired or inappropriate angiogenesis or proliferation of endothelial cells. The present invention is also directed to pharmaceutical compositions comprising (a) neomycin or an analogue and, optionally, (b) another anti-angiogenic agent or an anti-neoplastic agent. The present invention is further directed to a method for screening neomycin analogues having anti-angiogenic activity. A preferred embodiment of the invention relates to using neomycin to treat subjects having such diseases.
Claims63
A method of inhibiting pathological angiogenesis or proliferation of endothelial cells in a subject, which method comprises administering to the subject an amount of neomycin or an analogue thereof sufficient to inhibit pathological angiogenesis or proliferation of endothelial cells.
A method of inhibiting pathological angiogenesis or proliferation of endothelial cells in a subject, which method comprises administering to the subject a therapeutic amount of (a) neomycin or an analogue thereof, and (b) an anti-angiogenic agent that is not neomycin or an analogue thereof, sufficient to inhibit pathological angiogenesis or proliferation of endothelial cells.
A pharmaceutical composition comprising a therapeutically effective amount of (a) neomycin or an analogue thereof, and (b) an anti-angiogenic agent that is not neomycin or an analogue thereof, together with a pharmaceutically acceptable carrier, said amount sufficient to suppress pathological angiogenesis or proliferation of endothelial cells in a subject.
A pharmaceutical composition comprising a therapeutically effective amount of (a) neomycin or an analogue thereof, and (b) an anti-neoplastic agent, together with a pharmaceutically acceptable carrier, said amount sufficient to treat an angiogenesis-related disease which is a tumor in a subject.
A method for selecting a neomycin analogue for use in inhibiting angiogenesis or proliferation of endothelial cells, comprising testing the neomycin analogue for activity for inhibiting angiogenesis.
Dependencies are inferred from the claim text.