Temperature sensitive gel for sustained delivery of protein drugs
AssigneeUniversity Technology Corporation
InventorsLewis P. Stratton, John F. Carpenter, Mark C. Manning
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Abstract
Pharmaceutical compositions for the delivery of pharmacologically active proteins are provided by the present invention. The compositions of the present invention comprise a polymeric matrix having thermal gelation properties in which is incorporated a discrete suspension of at least one biologically active macromolecular polypeptide which retains greater than 90 percent of its biological activity. Furthermore, the concentration of the macromolecular polypeptide is greater than 0.5 percent by weight of the composition.
Claims10
A method of varying the liquid-gel transition temperature of a polyoxyalkylene block copolymer having the formula:
- HO(C2H4O)b(C3H6O)a(C2H4O)bH, wherein a is 20 to 80 and b is 15 to 60, the method comprising adding a solute selected from the group consisting of a sugar and a polyether glycol to an aqueous solution of said copolymer so as to increase or decrease said transition temperature.
A method of varying the liquid gel transition temperature of a polyoxyalkylene block copolymer comprising adding a solute selected from the group consisting of a sugar and a polyether glycol to an aqueous solution of the copolymer so as to increase or decrease the transition temperature.
Dependencies are inferred from the claim text.