US 6,482,231 B1 · Biological material for the repair of connective tissue defects comprising mesenchymal stem cells and hyaluronic acid derivative

Biological material for the repair of connective tissue defects comprising mesenchymal stem cells and hyaluronic acid derivative

OwnerGiovanni Abatangelo, Lanfranco Callegaro +10inventors

InventorsGiovanni Abatangelo, Lanfranco Callegaro, Randell G. Young, Josephine Mary Murphy, David Jordan Fink, Scott Philip Bruder, Francis Peter Barry, Sudhakar Kadiyala, Arnold I. Caplan, Roland Moskowitz, Jung U. Yoo, Luis A. Solchaga

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Abstract

A biological material for the repair of connective tissue cells comprising: a) a cell preparation enriched in mesenchymal stem cells, b) three-dimensional extracellular matrix comprising a nyaluronic acid derivative. The use of said biological material, optionally combined with therapeutically acceptable excipients and/or diluents and optionally in association with therapeutically effective ingredients in the repair of connective tissue cells.

Claims16

Dependent claims

A biological material for the repair of connective tissue defects comprising:

a) a cell preparation enriched in mesenchymal stem cells which is able to differentiate into more than one connective tissue cell line in the presence of a mesenchymal specific differentiation agent for said connective tissue cell line;
b) a three dimensional matrix comprising a hyaluronic acid derivative is selected from the group consisting of:
a partial or complete ester of hyaluronic acid with an aliphatic, aromatic or araliphatic alcohol, and
a crosslinked hyaluronic acid derivative.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

09/602,033Filed 23 Jun 2000 · continuation

Priority

IT PD95A022520 Nov 1995

Granted

19 Nov 2002

Term ends

Not estimatedThe source records don’t support an estimate.

Classification25 codes

A61L 27/3886
Containing added animal cells: comprising two or more cell types
A61L 15/28
Containing macromolecular materials: polysaccharides or their derivatives
A61L 27/20
Macromolecular materials: polysaccharides
A61L 27/3804
Containing added animal cells: characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells

Family

PCT/EP96/05093Parent of this continuation-in-part · filed 19 Nov 1996

Application09/041,287Parent of this continuation-in-part · filed 12 Mar 1998

Application09/039,200Parent of this continuation · filed 13 Mar 1998

Application09/039,200Parent of this continuation-in-part · filed 13 Mar 1998

US 6,596,274 B1Related patent

US 6,482,231 B1This patent

From the US filing history. Foreign family members aren’t listed.