Process for the preparation of N-carboxyanhydrides
AssigneeIsochem
InventorsFabrice Cornille, Jean-Luc Copier, Jean-Pierre Senet, Yves Robin
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Abstract
The invention relates to a process for the preparation of N-carboxyanhydrides by reaction of the corresponding amino acid with phosgene, diphosgene and/or triphosgene in a solvent medium, characterized in that the reaction is a least partially carried out in the presence of an unsaturated organic compound which has one or more ethylenic double bonds, one of the carbon of at least one ethylenic double bond of which is completely substituted by substituents other than halogen atoms. The N-carboxyanhydrides are thus obtained with better yields and an improved purity.
Claims12
Process for the preparation of N-carboxyanhydrides by reaction of the corresponding α-, β- or γ-amino acid or of one of its salts with phosgene, diphosgene and/or triphosgene in a solvent medium, wherein the reaction is at least during a portion of its duration carried out in the presence of an unsaturated organic compound which has one or more ethylenic double bonds, the remainder of the molecule of which is inert with respect to compounds present in the medium and one of the carbons of at least one ethylenic double bond of which is completely substituted by substituents other than halogen atoms.
Dependencies are inferred from the claim text.