Substituted stilbenes as glucose uptake enhancers

A compound of formula I:

• where
• R1, R2, 3, and R4 are, independently, hydrogen, hydroxyl, or optionally substituted lower alkyloxy;
• R5 is hydrogen, lower alkyl, substituted lower alkyl, or aryl;
• R6 is —C(O)OR13, where R13 is hydrogen or lower alkyl;
• R7 is hydrogen, lower alkyl or —C(O)OR13, where R13 has the above meaning;
• R8 and R9 are, independently, hydrogen, lower alkyl, substituted lower alkyl, halo, hydroxyl, lower alkoxy, carboxyl, —NR11R12, or —C(O)NR11R12, where R11 and R12 are, independently, hydrogen, lower alkyl, substituted lower alkyl aryl, substituted aryl, aryl(lower)alkyl, substituted aryl(lower)alkyl, heteroaryl(lower)alkyl substituted heteroaryl(lower)alkyl, heterocyclyl, substituted heterocyclyl, heteroaryl or substituted heteroaryl,
• R10 is hydrogen, lower alkyl, substituted lower alkyl, halo, hydroxy, lower alkoxy, —C(O)OR13 where R13 has the above meaning, —SO3H, or —C(O)NR11R12, where R11 and R12 have the above meanings;
• or a pharmaceutically acceptable salt thereof;
• as a single stereoisomer or mixture of stereoisomers.