Humanized antibody and uses thereof
AssigneesDana-Farber Cancer Institute, Inc., Avant Immunotherapeutics, Inc., Chiron Corporation
InventorsWayne A. Marasco, Joyce Lavecchio, Abner Mhashilkar, Urban Ramstedt, David Ring, Bridget Eberhardt, Julie Porter-Brooks
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Abstract
A humanized antibody framework motif is described. Preferably, the motif is encoded by the VH gene of K5B8 and the VL gene of TR1.6. This humanized antibody preferably contains the variable region of a tat antibody.
Claims32
A. humanized antibody framework motif wherein said framework has been selected from a human library based upon comparison to a murine antibody, and the heavy chain is encoded by the VH gene of K5B8, and the light chain is encoded by the VL gene of TR1.6
Dependencies are inferred from the claim text.