Oral administration of lactobacillus for the treatment and prevention of urogenital infection
AssigneeUrex Biotex, Inc.
InventorsAndrew W. Bruce, Gregor Reid
Life of this patent
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Abstract
The present invention provides methods and compositions for the oral administration of Lactobacillus and/or other probiotic organisms, such as Bifidobacterium, for establishment and maintenance of a healthy urogenital flora. The invention also provides methods and compositions to reduce the risk of disease.
Claims17
A method of establishing a healthy urogenital flora in females throughout life comprising orally administering a therapeutically effective amount of at least one probiotic organism selected from the group consisting of Lactobacillus rhamnosus GR-1 (ATCC 55826), L. rhamnosus GR-2 (ATCC 55915), L. rhamnosus GR-3 (ATCC 55917), L. rhamnosus GR-4 (ATCC 55916), L. rhamnosus RC-17 (ATCC 55825), L. rhamnosus RC-12 (ATCC 55895), L. jensenii RC-11 (ATCC 55920), L. acidophilus ATCC 4357, L. acidophilus RC-14 (ATCC 55845), L. plantarum RC-20 (ATCC 55883), L. plantarum RC-6 (ATCC 55894), L. fermentum A-60 (ATCC 55896), L. fermentum B-54 (ATCC 55884), and a pharmaceutically acceptable carrier.
A method of maintaining a healthy urogenital flora in females prior to, during and after pregnancy comprising orally administering at least one probiotic organism selected from the group consisting of Lactobacillus rhamnosus GR-1 (ATCC 55826), L. rhamnosus GR-2 (ATCC 55915), L. rhamnosus GR-3 (ATCC 55917), L. rhamnosus GR-4 (ATCC 55916), L. rhamnosus RC-17 (ATCC 55825), L. rhamnosus RC-12 (ATCC 55895), L. jensenii RC-11 (ATCC 55920), L. acidophilus ATCC 4357, L. acidophilus RC-14 (ATCC 55845), L. plantarum RC-20 (ATCC 55883), L. plantarum RC-6 (ATCC 55894), L. fermentum A-60 (ATCC 55896), L. fermentum B-54 (ATCC 55884), and a pharmaceutically acceptable carrier.
A method of treating and preventing urogenital infections in women comprising orally administering at least one Lactobacillus selected from the group consisting of Lactobacillus rhamnosus GR-1 (ATCC 55826), L. rhamnosus GR-2 (ATCC 55915), L. rhamnosus GR-3 (ATCC 55917), L. rhamnosus GR-4 (ATCC 55916), L. rhamnosus RC-17 (ATCC 55825), L. rhamnosus RC-12 (ATCC 55895), L. jensenii RC-11 (ATCC 55920), L. acidophilus ATCC 4357, L. acidophilus RC-14 (ATCC 55845), L. plantarum RC-20 (ATCC 55883), L. plantarum RC-6 (ATCC 55894), L. fermentum A-60 (ATCC 55896), L. fermentum B-54 (ATCC 55884), and a pharmaceutically acceptable carrier.
A method of improving and restoring the urogmnital microenvironment comprising orally administering at least one Lactobacillus selected from the group consisting of Lactobacillus rhamnosus GR-1 (ATCC 55826), L. rhamnosus GR-2 (ATCC 55915), L. rhamnosus GR-3 (ATCC 55917), L. rhamnosus GR-4 (ATCC 55916), L. rhamnosus RC-17 (ATCC 55825), L. rhamnosus RC-12 (ATCC 55895), L. jensenii RC-11 (ATCC 55920), L. acidophilus ATCC 4357, L. acidophilus RC-14 (ATCC 55845), L. plantarum RC-20 (ATCC 55883), L. plantarum RC-6 (ATCC 55894), L. fermentum A-60 (ATCC 55896), L. fermentum.
A method of inhibiting urogenital pathogen colonization of the urogenital tract in humans comprising oral administration of at least one Lactobacillus rhamnosus GR-1 (ATCC 55826), L. rhamnosus GR-2 (ATCC 55915), L. rhamnosus GR-3 (ATCC 55917), L. rhamnosus GR-4 (ATCC 55916), L. rhamnosus RC-17 (ATCC 55825), L. rhamnosus RC-12 (ATCC 55895), L. jensenii RC-11 (ATCC 55920), L. acidophilus ATCC 4357, L. acidophilus RC-14 (ATCC 55845), L. plantarum RC-20 (ATCC 55883), L. plantarum RC-6 (ATCC 55894), L. fermentum A-60 (ATCC 55896), L. fermentum B-54 (ATCC 55884), and a pharmueutically acceptable carrier.
A method of reducing the biofilm load of urogenital pathogens comprising orally administering at least one Lactobacillus selected from the group consisting of Lactobacillus rhamnosus GR-1 (ATCC 55826), L. rhamnosus GR-2 (ATCC 55915), L. rhamnosus GR-3 (ATCC 55917), L. rhamnosus GR-4 (ATCC 55916), L. rhamnosus RC-17 (ATCC 55825), L. rhamnosus RC-12 (ATCC 55895), L. jensenii (ATCC 55920), L. acidophilus ATCC 4357, L. acidophilus RC-14 (ATCC 55845), L. plantarum RC-20 (ATCC 55883), L. plantarum RC-6 (ATCC 55894), L. fermentum A-60 (ATCC 55896), L. fermentum B-54 (ATCC 55884), in an amount effective to colonize the intestine and the vagina.
A method of delivering a probiotic organism to the vagina comprising orally administering at least one Lactobacillus selected from the group consisting of Lactobacillus rhamnosus GR-1 (ATCC 55826), L. rhamnosus GR-2 (ATCC 55915), L. rhamnosus GR-3 (ATCC 55917), L. rhamnosus GR-4 (ATCC 55916), L. rhamnosus RC-17 (ATCC 55825), L. rhamnosus RC-12 (ATCC 55895), L. jensenii RC-11 (ATCC 55920), L. acidophilus ATCC 4357, L. acidophilus RC-14 (ATCC 55845), L. plantarum RC-20 (ATCC 55883), L. plantarum RC-6 (ATCC 55894), L. fermentum A-60 (ATCC 55896), L. fermentum B-54 (ATCC 55884), and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.