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AssigneeOsteotech, Inc.
InventorsJohn M. Winterbottom, Lawrence Shimp, Todd M. Boyce, David Kaes
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An implant is provided as a solid aggregate of bone-derived elements, e.g., particles, powders, granules, fibers, strips and/or large pieces of xenogenic, allogenic, transgenic, tissue engineered or autologous cortical and/or cancellous bone, employing as binding agent for the bone-derived elements a precipitate or crystalline bridge of metal oxide, metal hydroxide, metal salt of an inorganic acid, metal salt of an organic acid, metal-containing silica based glass, or mixture thereof, the binding agent possessing at least slight solubility in polar solvent, adjacent bone-derived elements being bonded to each other through engagement with particles or bridge-like structures of bonding agent.
An implant which comprises a solid aggregate of bone-derived elements in which the surfaces of individual bone-derived elements possess one or more binding agents selected from the group consisting of metal oxide, metal hydroxide, metal salt of an inorganic acid, metal salt of an organic acid and metal-containing silica-based glass, the binding agent possessing at least slight solubility in a polar solvent, adjacent bone-derived elements in the aggregate being bonded to each other through engagement with the binding agent.
A method of making an implant made up of a solid aggregate of bone-derived elements which comprises:
A method of making an implant made up of a solid aggregate of bone-derived elements which comprises contacting the surfaces of a quantity of bone-derived elements with a dry metal salt and initiating a crystallization reaction involving the salt to provide a biocompatible binding agent of crystallized salt on the surfaces of the bone-derived elements, adjacent bone-derived elements being bonded to each other through engagement with the binding agent.
Dependencies are inferred from the claim text.