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US 6,476,279 B2Granted
Method of making fluorinated alcohols
AssigneeHoneywell International Inc.
InventorsHaridasan K. Nair, Andrew Joseph Poss
Life of this patent
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Abstract
Disclosed are methods of producing fluorinated alcohols which find particular use in the syntheses of pharmaceutical drugs. The methods comprise generally, the steps of (a) reacting a halogenated alkane with an alkyl vinyl ether to form an unsaturated halogenated aldehyde; (b) reducing the unsaturated halogenated aldehyde to form an unsaturated halogenated alcohol; and (c) reducing the unsaturated halogenated alcohol to form a fluorinated alcohol.
Claims28
A method for the preparation of fluorinated alcohol compounds comprising the steps of:
- (a) reacting a halogenated alkane having at least one fluorine substituent with an ether reactant selected from the group consisting of alkyl vinyl ethers, cycloalkyl vinyl ethers, aryl vinyl ethers, and combinations of two or more thereof, to form a halogenated unsaturated aldehyde;
- (b) reducing said halogenated unsaturated aldehyde to form a halogenated unsaturated alcohol;
- and
- (c) reducing said halogenated unsaturated alcohol to form a fluorinated alcohol.
1 more element
Dependencies are inferred from the claim text.