2-aroyl-4-acyl paclitaxel (Taxol) analogs
AssigneesBristol-Myers Squibb Company, Virginia Tech Intellectual Properties, Inc.
InventorsDavid George Ian Kingston, Mahendra Devichand Chordia, Prakash G. Jagtap, John Kadow
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Abstract
2-debenzoyl-4-deacetyl paclitaxel, antineoplastic analogs thereof and intermediates are taught, as well as the formation of the compound, analogs and intermediates. The compound, analogs and intermediates may be used to form pharmaceutical compositions having anti-neoplastic activity. Further, the compound, analogs and intermediates may be used to treat cancer when applied in an effective amount by means such as a pharmaceutical composition.
Claims3
An antineoplastic compound, or a pharmaceutically acceptable salt thereof, comprising the general formula:
- wherein R1 is an aryl or substituted aryl;
- R2 is an aryl or substituted aryl;
- R3 is OC(O)CH3;
- R4 is OH;
- R5 is S-methyldithiocarboxyoxy;
- and R6 is OC(O)Rg, wherein Rg is selected from the group consisting of alkyls, cycloalkyls, heterocycloalkyls, heterocycloaryls, alkenyls, alkynyls, aryls, and substituted aryls.
An antineoplastic compound, or a pharmaceutically acceptable salt thereof, comprising the general formula:
- wherein R1 is an aryl or substituted aryl;
- R2 is an aryl or substituted aryl;
- R3 is OC(O)CH3;
- R4 is OH;
- R5 is S-methyldithiocarboxyoxy;
- and R6 is selected from the group consisting of m-methoxybenzol, m-chlorobenzoyloxy and m-azidobenzoyloxy.
An antineoplastic compound, or a pharmaceutically acceptable salt thereof, comprising the general formula:
- wherein R1 and R2 are phenyl;
- R3 is OC(O)CH3;
- R4 is OH;
- R5 is cyclopropylcarbonyloxy;
- and R6 is 2,4-difluorobenzoyloxy.
Dependencies are inferred from the claim text.