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US 6,476,233 B1Granted
Transition metal-catalyzed reactions based on chiral amine oxazolinyl ligands and related compounds
AssigneeThe Penn State Research Foundation
InventorXumu Zhang
Life of this patent
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Abstract
This invention is to develop novel transition metal catalysts for the practical synthesis of important chiral molecules. The invention emphasizes asymmetric catalysis based on chiral amine oxazolinyl ligands and related ligands. Specially, a direct asymmetric hydrogenation system based on Ru-Ambox catalyst was discovered.
Claims13
A compound selected from the enantiomer of formula (I), (II), and (III):
- in which R, R1, R2, R3, R4, R5, R6, R7 and R8, are each independently selected to be the same or different and are selected from a hydrogen atom, an alkyl radical, an aryl radical, a substituted alkyl radical, and substituted aryl radical;
- wherein any two of R1, R2, R3, and R4 when linked together form a ring;
- X is chosen from PR′, PH, O, S, Se, AsR′, AsH, SiR′H, GeR′H, NH, NR′, NR′2, NCOR′, NOH, NNHR′, and NNHCOR′, wherein R′ is selected from an alkyl radical, an aryl radical, a substituted alkyl radical, and a substituted aryl radical;
- and
- n is 1 or 2.
2 more elements
Dependencies are inferred from the claim text.