4-(2-amino-1-hydroxyethyl)oxazoline derivative and method for producing same

A method for producing a 4-(2-amino-1-hydroxyethyl)oxazoline derivative of the formula [XIII]

• wherein R4 is an optionally substituted alkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl or an optionally substituted heteroarylalkyl, and R6 and R7 are the same or different and each is a hydrogen atom, an optionally substituted alkyl, an optionally substituted aryl, an optionally substituted heteroaryl or an optionally substituted aralkyl, or R6 and R7 combinedly form, together with the adjacent nitrogen atom, a hetero ring, said hetero ring being optionally substituted by halogen atom, alkyl, alkenyl, alkoxy, amino, alkoxycarbonyl, carboxamide or alkyl-substituted carbamoyl, or an enantiomer thereof, comprising treating an oxazoline derivative of the formula [X]
• wherein R4 is as defined above, R5 is a hydrogen atom or an acyl, and Z is a substituent which functions as a leaving group together with an oxygen atom, or an enantiomer thereof with a base to give an (oxazolin-4-yl)oxyrane derivative of the formula [XI]
• wherein R4 is as defined above, or an enantiomer thereof, and reacting the resulting derivative [XI] with an amine of the formula [XII]
• wherein R6 and R7 are as defined above.