Process for the preparation of N-carboxy-t-leucine anhydride
AssigneeDsm N.V.
InventorsRobert P Hof, Wilhelmus Zwaan
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Abstract
Process for the preparation of N-carboxy-t-leucine anhydride in which the corresponding N-carboxy-t-leucine is subjected to a cyclization with the aid of an acyl halogenide. Preferably, acetyl chloride is used as acyl halogenide. The N-carboxy-t-leucine anhydride obtained optionally is subsequently converted into a t-leucine-N-substituted amide with the aid of the corresponding amine. Preferably, methyl amine is chosen as the amine, and the reaction is carried out in a mixture of water and methanol as solvent.
Claims13
A process which comprises subjecting N-carboxy-t-leucine to a cyclization reaction with an acyl halide to prepare an N-carboxy-t-leucine anhydride of formula (I)
A process which comprises cyclizing N-carboxy-t-leucine with from 1.05 to 1.2 equivalents of acetyl chloride at a temperature of form 0° C. to prepare and N-carboxy-t-leucine anhydride of formula (I)
Dependencies are inferred from the claim text.