Method for producing ar(alk)yluraciles, novel corresponding intermediate products and method for producing said intermediate products
AssigneeBayer Aktiengesellschaft
InventorsBernd Gallenkamp, Reinhard Lantzsch, Lothar Rohe, Lubbertus Mulder
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Abstract
The invention relates to a process for preparing ar(alk)yluracils of the general formula (I) in which A represents a single bond or represents alkanedlyl, Ar represents optionally substituted aryl, R1 represents optionally substituted alkyl and R2 represents hydrogen, halogen or alkyl, and to novel intermediates for this purpose and to processes for their preparation.
Claims5
A process for preparing a substituted aminoalkenamide of the formula (IIa)
- comprising reacting a substituted pyrimidone of the formula (III)
- wherein
- A represents a single bond or represents alkanediyl,
- Ar represents optionally substituted aryl,
- R1 represents optionally substituted alkyl and
- R2 represents hydrogen, halogen or alkyl, at temperatures between 0° C. and 100° C. with an acid, if appropriate in the presence of a diluent.
A process for preparing a substituted aminoalkenamide of the formula (IIb)
- comprising reacting a substituted oxazinone of the formula (IV)
- wherein
- R1 represents optionally substituted alkyl and
- R2 represents hydrogen, halogen or alkyl, with an ar(alk)ylamines of the formula (V)
- H2N—A—Ar (V)
- wherein
- A represents a single bond or represents alkanediyl, and
- Ar represents optionally substituted aryl, at temperatures between 0° C. and 150° C., if appropriate in the presence of a diluent.
A substituted pyrimidone of the (III)
- wherein
- A represents a single bond or represents alkanediyl,
- Ar represents optionally substituted aryl,
- R1 represents optionally substituted alkyl and
- R2 represents hydrogen, halogen or alkyl.
A process for preparing a substituted pyrimidone of the formula (III)
- comprising reacting a substituted aminoalkenamide of the formula (VI)
- wherein
- A represents a single bond or represents alkanediyl,
- Ar represents optionally substituted aryl,
- R1 represents optionally substituted alkyl and
- R2 represents hydrogen, halogen or alkyl with dichloromethylene-dimethylimmonium chloride of the formula (VII)
- Cl2C═N(CH3)2 Cl (VII)
- at temperatures between 0° C. and 100° C. in the presence diluent.
A process for preparing a ar(alk)yluracil of the formula (I)
- wherein
- A represents a single bond or represents alkanediyl,
- Ar represents optionally substituted aryl,
- R1 represents optionally substituted alkyl and
- R2 represents hydrogen, halogen or alkyl, comprising the steps of:
- a) reacting a substituted aminoalkenamide of the general formula (VI)
- wherein A, Ar, R1 and R2 are as defined above with dichloromethylene-dimethylimmonium chloride of the formula (VII)
- Cl2C═N(CH3)2Cl (VII)
- at temperatures between 0° C. and 100 °C. in the presence of a diluent;
- b) reacting the substituted pyrimidone of the formula (III) prepared in step a)
- wherein A, Ar, R1 and R2 are as defined above at temperatures between 0° C. and 100° C. with an acid, if appropriate in the presence of a diluent, and
- c) heating of the substituted aminoalkenamide of the general formula (IIa) prepared in step b)
- wherein A, Ar, R1 and R2 are as defined above at temperatures between 40° C. and 120° C., if appropriate in the presence of a diluent.
Dependencies are inferred from the claim text.