Method for obtaining N-[3(3-cyano-pyrazole[1,5-a]pyrimidine-7-yl)phenyl]-N-ethyl-acetamide

Abstract

An improved method for preparing N-[3(3-cyanopyrazole[1,5-a]pyrimidine-7-yl)phenyl]-N-ethyl-acetamide having the FORMULA I: in which the product in question is obtained in “a single step” starting with N-[3-[3-(dimethylamine)-1-oxo-2-propenyl]phenyl]acetamide (II) according to the following sequence: In a first stage N-[3-[3-(dimethylamine)-oxo-2-propenyl]phenyl]acetamide (II) is added in portions to a suspension of sodium hydride in dimethylformamide in the presence of ethyl iodide. The resulting suspension of compound (III) (N-[3-[3-(dimethylamine)-1-oxo-2-propenyl]phenyl]-N-ethyl-acetamide) is diluted with water until solution A is obtained which is used as it is. Subsequently, solution A is added to solution B of 3-amino-pyrazole-4-carbonitrile IV) in aqueous DMF/hydrochloric acid.

Dependencies are inferred from the claim text.