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US 6,476,220 B2Granted
Process for the preparation of furaca
AssigneeAurobindo Pharma Ltd
InventorsUthira Kumar, Meenakshisunderam Sivakumaran, Vijay Kumar Handa
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Abstract
A process is disclosed for the preparation of 7-amino-3-(2-furanylcarbonylthiomethyl)-3-cephem-4-carboxylic acid (also known as Furaca). The process comprises of the steps of reacting 7-aminocephalosporanic acid with a mixture of 2-thiofuric acid and Boron Trifluoride in a solvent and precipitating Furaca as a solid.
Claims3
A process to prepare a cephalosporin compound of the formula
- comprising of the steps of:
- preparing a catalyst solution of Boron Trifluoride in an organic solvent or in a mixture of organic solvents,
- mixing into said catalyst solution of 2-Thiofuric Acid of the formula
- in a solvent to form a reactant mixture,
- reacting 7-Aminocephalosporanic acid with the said reactant mixture,
- precipitating from the said reaction mixture Furaca as a solid.
3 more elements
Dependencies are inferred from the claim text.