Cloning and characterization of FLBA gene of H. pylori production of aflagellate
AssigneesInstitut Pasteur, Institut National de la Sante et de la Recherche Medicale
InventorsSebastian Suerbaum, Agnès Labigne
Life of this patent
Estimating the term…
Abstract
The present application relates to nucleotide sequences which regulate the biosynthesis of the flagella proteins Helicobacter pylori, to the proteins encoded by these sequences and to aflagellate bacterial strains. The invention also relates to the use of these means for detecting an infection due to H . pylori or for protecting against such an infection.
Claims11
A purified polynucleotide comprising SEQ ID NO:
- 6.
A purified polynucleotide comprising the full LAW OFFICES complement of SEQ ID NO:
- 6.
An oligonucleotide probe comprising SEQ ID NO:
- 3.
An oligonucleotide comprising the full complement of SEQ ID NO:
- 3.
A purified polynucleotide comprising SEQ ID NO:6 modified by insertion of a polynucleotide sequence encoding resistance to an antibiotic or resistance to a heavy metal.
A purified polynucleotide comprising SEQ ID NO:
- 6 modified by insertion of a cassette encoding resistance to kanamycin.
A purified polynucleotide selected from the group consisting of:
- (a) a purified polynucleotide consisting of SEQ ID NO:6;
- (b) a purified polynucleotide consisting of the full complement of SEQ ID NO:6;
- (c) an oligonucleotide consisting of SEQ ID NO:3;
- (d) an oligonucleotide consisting of the full complement of SEQ ID NO:3;
- (e) a purified polynucleotide consisting of SEQ ID NO:6 modified by insertion of a polynucleotide sequence encoding resistance to an antibiotic or resistance to a heavy metal;
- and
- (f) a purified polynucleotide consisting of SEQ ID NO:6 modified by insertion of a polynucleotide sequence encoding resistance to kanamycin.
Dependencies are inferred from the claim text.