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US 6,476,207 B1Granted
Genes and gene expression products that are differentially regulated in prostate cancer
AssigneeChiron Corporation
InventorsJimmy Zhang, Jon H. Astle, Eddie Carroll, III, Wilson O. Endege, Donna M. Ford, John E. Monahan, Robert Schlegel, Kathleen E. Steinmann
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Abstract
This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The invention further relates to polynucleotides differentially expressed in prostate cancer.
Claims6
An isolated nucleic acid molecule selected from the group consisting of:
- (a) a polynucleotide consisting of the nucleotide sequence from the group consisting of SEQ ID NO:
- 153 and 154;
- (b) a polynucleotide that is a degenerate variant of SEQ ID NO:
- 153 or SEQ ID NO:
- 154;
- and
- (c) a polynucleotide that is the complement of (a) or (b).
4 more elements
A diagnostic kit comprising:
- (a) a polynucleotide probe that consists of at least 12 contiguous nucleotides of the nucleotide sequence from the group consisting of SEQ ID NO:
- 153 and 154, or the complement thereof;
- (b) a normal biological sample;
- and
- (c) instructions for detecting differences that exist between the levels of hybridization between the probe and a test biological sample as compared to the level of hybridization between the probe and said normal biological sample.
2 more elements
Dependencies are inferred from the claim text.