US 6,476,198 B1Granted

Multispecific and multivalent antigen-binding polypeptide molecules

AssigneeThe Scripps Research Institute

InventorAngray Singh Kang

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The present invention relates to multispecific and multivalent antigen-binding polypeptides and methods for producing them.

Dependent claims

A composition comprising a bivalent single chain polypeptide having an amino acid residue sequence according to the formula:

Fv—X—Fv,
wherein Fv is an antigen binding site having an immunoglobulin variable heavy and light chain domain selected from the group consisting of VH/VL and VL/VH, and X is an immunoglobulin constant domain.

Dependencies are inferred from the claim text.

C07K 16/26
Against material from animals or humans: against hormones ; against hormone releasing or inhibiting factors
C07K 16/2809
Against the immunoglobulin superfamily: against the T-cell receptor -CD3 complex
C07K 16/2812
Against the immunoglobulin superfamily: against CD4
C07K 16/44
Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies: against material not provided for elsewhere , e.g. haptens, metals, DNA, RNA,…

From the US filing history. Foreign family members aren’t listed.

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