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AssigneeKorea Institute of Science and Technology
InventorsYoung Ha Kim, Soo Hyun Kim, Ki Dong Park, Soo-Hong Lee
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The present invention relates to polyethyleneglycol/polylactide(or polyglycolide or polycaprolactone)/polyethyleneglycol triblock copolymers with an enhanced reactivity, and process for their preparation. More specifically, the present invention is directed to triblock copolymers that are obtained by the process comprising the step of synthesizing a polylactide(or polyglycolide or polycaprolactone) having hydroxy groups at both ends and the step of coupling said polylactide with polyethyleneglycol having an acylhalide group of a high reactivity at one of its ends, and the process for preparing the same Since the triblock copolymer according to the present invention has an ester structure with good biocompatibility, it can be applied extensively for biomaterials used in tissue engineering, in a matrix that slowly releases drugs, etc.
A biodegradable triblock copolymer selected form the group consisting of copolymers of formulae (1) to (4):
A method for preparing a triblock copolymer which comprises coupling polyethyleneglycol having an acylhalide group of a high reactivity at one of its ends with polylactide, polyglycolide, polylactide/polyglycolide or polycaprolactone having a hydroxy group at both ends in the presence of pyridine.
Dependencies are inferred from the claim text.