Platinum derivative pharmaceutical formulations
AssigneePharmacia Italia S.p.A.
InventorsSara Lauria, Alessandro Martini, Cristina Ciocca
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Abstract
The present invention relates to novel stable solution formulations comprising oxaliplatin, an effective stabilizing amount of lactic acid and/or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. A method for manufacturing such formulations ready for administration and their use in the antitumor therapy are also within the scope of the invention.
Claims29
Stable oxaliplatin solution formulation comprising a formulation selected from the group consisting of:
- (a) oxaliplatin, an effective stabilizing amount of lactic acid, and a pharmaceutically acceptable carrier;
- (b) oxaliplatin, an effective stabilizing amount of a pharmaceutically acceptable salt of lactic acid, and a pharmaceutically acceptable carrier;
- and
- (c) oxaliplatin, an effective stabilizing amount of lactic acid and a pharmaceutically acceptable salt of lactic acid, and a pharmaceutically acceptable carrier.
Stable oxaliplatin solution formulation comprising oxaliplatin, an effective stabilizing amount of lactic acid and a pharmaceutically acceptable carrier.
A method for stabilizing a formulation of oxaliplatin, which comprises adding an effective stabilizing amount of lactic acid or a pharmaceutically acceptable salt thereof or both to an aqueous carrier and then dissolving oxaliplatin in said carrier.
Dependencies are inferred from the claim text.