US 6,476,062 B2Granted

Chemokine receptor antagonists

AssigneeSchering Corporation

InventorsMin Chu, Ronald A. Mierzwa, Joseph Terracciano, Mahesh G. Patel

Life of this patent

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Abstract

Novel tetramic acid-type compounds isolated from a CCR-5 active complex produced by fermentation under controlled conditions of a biologically pure culture of the microorganism, Chaetomium globosum Kunze SCH 1705, ATCC 74489., pharmaceutical compositions containing the compounds and the use of the CCR-5 antagonist compounds and compositions to treat HIV-1 infections in humans are disclosed.

Claims8

Dependent claims

A compound represented by the formula I or II or III:

in substantially chemically pure form, or a pharmaceutically acceptable salt thereof.

Dependencies are inferred from the claim text.

Facts

Application: 09/815,853Filed 23 Mar 2001 · us provisional application
Priority: 30 Mar 2000
Published: US 2002/0128307 A112 Sep 2002
Granted: 5 Nov 2002
Term ends: Not estimatedThe source records don’t support an estimate.

Classification11 codes

C07D 207/44
With only hydrogen or carbon atoms directly attached to the ring nitrogen atom: having three double bonds between ring members or between ring…
A61P 31/18
For RNA viruses: for HIV
A61P 43/00
Drugs for specific purposes, not provided for in groups a61p1/00-a61p41/00
C12N 1/145
Fungi ; Culture media therefor: fungi isolates

Family

Application60/193,331Us provisional application · filed 30 Mar 2000
US 2002/0128307 A1Pre-grant publication · published 12 Sep 2002
US 6,476,062 B2This patent

From the US filing history. Foreign family members aren’t listed.

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