Methods of pharmacological treatment using S(−) amlodipine
AssigneeIsotechnika Inc.
InventorRobert T. Foster
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Abstract
Methods and compositions are disclosed utilizing the optically pure S(−) isomer of amlodipine. This compound is a potent drug for the treatment of hypertension while avoiding the concomitant liability of adverse effects associated with the administration of the racemic mixture of amlodipine. The S(−) isomer of amlodipine is also useful for the treatment of angina and such other conditions as may be related to the activity of S(−) amlodipine as a calcium channel antagonist without the concomitant liability of adverse effects associated with the racemic mixture of amlodipine.
Claims5
A method for blocking calcium channels, while avoiding the concomitant liability of adverse effects associated with administration of racemic amlodipine, which comprises administering to an animal in need of calcium channel blocking therapy, an amount of deuterated S(−) amlodipine, or a pharmaceutically acceptable salt thereof, substantially free of its R(+) stereoisomer, wherein the deuterated S(−) amlodipine or salt thereof, comprises an amlodipine selected from the genus described by:
- wherein R represents either hydrogen or deuterium;
- and wherein R1 represents either hydrogen or deuterium, and at least one of the R or R1 is deuterium, said amount being sufficient to provide calcium channel blockade but insufficient to cause said adverse effects of racemic amlodipine.
A compound comprising deuterated S(−) amlodipine, or a pharmaceutically acceptable salt thereof, substantially free of the R(+) stereoisomer, wherein the deuterated S(−) amlodipine or salt thereof, comprises an amlodipine selected from the genus described by:
- wherein R represents either hydrogen or deuterium;
- and wherein R1 represents either hydrogen or deuterium, and at least one of the R or R1 is deuterium.
Dependencies are inferred from the claim text.