Antipsychotic heterocycle compounds
AssigneeBristol-Myers Squibb Company
InventorsRonald J. Mattson, Joseph P. Yevich, Jun Yuan, Arlene S. Eison, Derek Denhart
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Abstract
Compounds of Formula I: wherein Ar, Y, m, and Z are as defined in the specification, are useful antipsychotic and antidepressant agents demonstrating potent inhibition of 5-HT reuptake and dopamine D2 receptor antagonism.
Claims9
A compound of Formula I and its pharmaceutically acceptable salts
- wherein:
- Y is selected from oxygen and sulfur;
- Z is selected from II and III;
- R1 and R4 are independently selected from hydrogen and lower alkyl;
- R5 is selected from hydrogen, halogen, lower alkoxy and cyano;
- R8 and R7 are independently selected from hydrogen, halogen, and lower alkoxy;
- m is an integer from 2 to 6;
- and a dotted line represents an optional double bond.
A compound of claim 2 wherein Z is II.
A method for treating a patient suffering from psychosis, acute mania, or depression in combination with psychotic episodes, comprising administration to the patient of a therapeutically effective amount of a compound of Formula IA and its pharmaceutically acceptable salts.
- wherein:
- Y is sulfur or oxygen;
- R4 is selected from H and lower alkyl;
- R2 and R3 are independently selected from H, halogen, and lower alkoxy;
- m is an integer from 2-6;
- and a dotted line represents an optional double bond.
Dependencies are inferred from the claim text.