Diazabicyclo[4.3.0]nonanes, and methods of use thereof

A compound represented by A:

• wherein
• Z represents NR, NC(O)R, NS(O)2R, O, S, SO, or SO2;
• m is independently for each occurrence 0, 1, 2, 3, or 4;
• y is 0, 1, or 2;
• R represents H, alkyl, cycloalkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl;
• R1 represents H, alkyl, cycloalkyl, aryl, or heteroaryl;
• R, when a constituent of Z, and R1 may be connected through a covalent bond;
• R4 represents independently for each occurrence H, alkyl, cycloalkyl, alkenyl, aryl, heteroaryl, acyl, or sulfonyl;
• R5 and R6 are selected independently for each occurrence from the group consisting of H, alkyl, CH2ZR, aryl, heteroaryl, F, OR, and OC(O)R;
• a covalent bond may connect R4 and an instance of R5 or R6;
• any geminal or vicinal pairs of R5 and R6 may be connected through a covalent bond;
• and
• the stereochemical configuration at any stereocenter of a compound represented by A is R, S, or a mixture of these configurations.