L-arginine and phosphodiesterase (PDE) inhibitor synergism
AssigneeThe Regents of the University of California
InventorArthur W. Wallace
Life of this patent
Estimating the term…
Abstract
This invention pertains to the discovery that L-arginine and type V phosphodiesterases act synergistically to inhibit vasospasm and/or to induce vasodilation. Methods are provided using combinations of L-arginine and type V phosphodiesterase inhibitors in the treatment of cardiac pathologies and/or the treatment of erectile dysfunction.
Claims44
A method for ameliorating erectile dysfunction in a male individual, comprising administering to the individual an effective amount of a pharmaceutical composition comprising a Type V phosphodiesterase inhibitor and L-arginine.
A method of inducing vasodilation or inhibiting vasospasm of a coronary artery or bypass graft, said method comprising contacting the coronary artery or bypass graft with L-arginine and a type V phosphodiesterase inhibitor, whereby said L-arginine and said type V phosphodiesterase inhibitor act synergistically to induce or increase vasodilation or to inhibit vasospasm of said coronary artery or bypass graft.
A pharmaceutical composition for inducing vasodilation or inhibiting vasospasm of a coronary artery or bypass graft, said composition comprising L-arginine and a type V phosphodiesterase inhibitor.
In a mammal, a coronary artery or bypass graft contacted with an exogenously supplied L-arginine and an exogenously supplied phosphodiesterase inhibitor whereby said L-arginine and said phosphodiesterase inhibitor act synergistically to induce vasodilation or reducing vasospasm of said coronary artery or bypass graft.
A kit for inducing vasodilation or inhibiting vasospasm of a coronary artery or bypass graft, said kit comprising one or more containers containing:
- L-arginine;
- and
- a type V phosphodiesterase inhibitor.
A kit for ameliorating erectile dysfunction, said kit comprising one or more containers containing:
- L-arginine;
- a type V phosphodiesterase inhibitor;
- and
- a beta blocker.
Dependencies are inferred from the claim text.