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US 6,476,020 B1Granted
Imidazo-benzazepine compounds, their compositions and uses
AssigneeThe Procter & Gamble Company
InventorsSong Liu, David Edward Portlock, Schwe Fang Pong
Life of this patent
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Abstract
The subject invention involves compounds having the structure: wherein the Cα—Nβ, C5-C6, and C6-C7 bonds are each single or double bonds, except that both C5-C6, and C6-C7 are double bonds; R1 is selected from hydrogen, alkyl, aryl, and heterocycle; R2-R15 are independently selected from hydrogen and other substituents; and pharmaceutically-acceptable forms thereof. The subject invention also involves pharmaceutical compositions containing such compounds, and methods for treating or preventing diseases and disorders using such compounds.
Claims20
A compound having the structure:
- wherein:
- (a) the bond between Cα and Nβ is a single bond, or a double bond whereby R2 (and H on Cα) are nil;
- (b) the bond between C5 and C6 is a single bond, or a double bond whereby R13 and R15 are nil;
- the bond between C6 and C7 is a single bond, or a double bond whereby R11 and R13 are nil;
- but the C5-C6 and C6-C7 bonds are not both double bonds;
- (c) R1 is selected from the group consisting of hydrogen, alkyl, aryl, and heterocycle;
- (d) R2, if not nil, is selected from the group consisting of hydrogen, alkyl, alkylacyl, and arylacyl;
- (e) R3, R4 and R5 are each independently selected from the group consisting of hydrogen, halo, alkyl, aryl, alkylaryl, alkylacyl, heterocycle, nitro, and cyano;
- or unsubstituted or alkyl- or aryl- or heterocycle-substituted hydroxy, thio, amino, amide, formyl, carboxy and carboxamide;
- or R3 and R4 together are alkylene or heteroalkylene attached to adjacent carbons of the phenyl to which R3 and R4 are attached thereby forming a ring fused to the phenyl ring of carbons 1′-6′, and R5 is as specified above;
- (f) R6, R7 and R8 are each independently selected from the group consisting of hydrogen, halo, alkyl, aryl, heterocycle, nitro, and cyano;
- or alkyl- or aryl- or heterocycle-substituted hydroxy, thio, amino, amide, sulfonamide, formyl, carboxy, and carboxamide;
- or R6 and R7 together are alkylene or heteroalkylene attached to adjacent carbons of the phenyl to which R6 and R7 are attached thereby forming a ring fused to the phenyl ring of carbons 8-11, and R8 is as specified above;
- (g) R9 is selected from the group consisting of hydrogen, halo, alkyl, aryl, heterocycle, and carboxy and its alkyl and aryl esters and amides;
- (h) R10, R12 and R14 and R11, R13 and R15 if not nil, are each independently selected from the group consisting of hydrogen, alkyl, and aryl;
- and an optical isomer, diastereomer or enantiomer thereof;
- and a pharmaceutically acceptable salt or hydrate thereof.
14 more elements
Dependencies are inferred from the claim text.