Pharmaceutical composition
AssigneeMitsubishi Pharma Corporation
InventorsAtsushi Sakai, Rumiko Masuda, Tsuneo Fujii, Tadashi Mishina, Kenji Chiba
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Abstract
Medicinal compositions which can be processed into solutions and are useful in inhibiting rejection reactions against the transplantation of organs or bone marrow, in the maintenance immunotherapy therefor or in treating autoimmune diseases, characterized by containing 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol or pharmaceutically acceptable acid-addition salts thereof and cyclodextrins as a stabilizer optionally together with saccharides, if required.
Claims21
A pharmaceutical compositions comprising:
- 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol or a pharmaceutically acceptable acid addition salt thereof as an active ingredient;
- a cyclodextrin;
- and
- a pharmaceutically acceptable carrier or diluent,
- wherein the active ingredient is contained in a proportion of 0.05-0.1% by weight in the composition, wherein said active ingredient is soluble in water at concentrations below 0.05% by weight and above 0.1% by weight, but has a tendency to form crystalline deposits from an aqueous solution upon standing only when dissolved in a proportion of 0.05-0.1% by weight, and
- wherein said cyclodextrin prevents said crystalline deposits from forming.
A method for preventing crystalline deposits of 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol or a pharmaceutically acceptable acid addition salt thereof, wherein said 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol and said pharmaceutically acceptable acid addition salt thereof are soluble in water at concentrations below 0.05% by weight and above 0.1% by weight, but have a tendency to form crystalline deposits from an aqueous solution upon standing only when dissolved in a proportion of 0.05-0.1% by weight of the composition, said method comprising adding a cyclodextrin to a composition comprising 0.05-0.1% by weight of said 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol, in prophylaxis or treatment of suppression of rejection, autoimmune diseases, or allergic diseases.
A method for lessening hemolysis or local irritation of 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol or a pharmaceutically acceptable acid addition salt thereof, wherein said 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol and said pharmaceutically acceptable acid addition salt thereof are soluble in water at concentrations below 0.05% by weight and above 0.1% by weight, but have a tendency to form crystalline deposits from an aqueous solution upon standing only when dissolved in a proportion of 0.05-0.1% by weight of the composition, said method comprising adding a cyclodextrin to a composition comprising 0.05-0.1% by weight of said 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol, in prophylaxis or treatment of suppression of rejection, autoimmune diseases, or allergic diseases.
Dependencies are inferred from the claim text.