Facilitation of repair of neural injury with CM101/GBS toxin
AssigneeVanderbilt University
InventorsCarl G. Hellerqvist, Artur W. Wamil, Barbara D. Wamil
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Abstract
Neural injury may be advantageously treated with CM101, a polysaccharide toxin isolated from Group B β-hemolytic Streptococcus bacteria. CM1O1 treatment aids in the re-establishment of neuronal connectivity, at least partially inhibits scar formation, and increases the probability of survival during the critical period following injury to the central nervous system. Preexisting neural injuries having scar tissue are ameliorated by surgical excision of the scar tissue in conjunction with administration of CM101.
Claims32
A method of treating a patient with a neutral injury, which method comprises:
- administering to the patient a polysaccharide toxin from group B β-hemolytic Streprococces (GBS) bacteria in a quantity sufficient to at least partially inhibit scar formation by impairing glial cell proliferation.
A method of treating a patient with a preexisting neural injury having scar tissue, which method comprises:
- excising the scar tissue, and
- administering a polysaccharide toxin from group B β-hemolytic Streptococcus (GBS) bacteria to the patient in a quantity sufficient to minimize scarring by impairing glial cell proliferation.
Dependencies are inferred from the claim text.