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US 6,475,997 B1Granted
Methods of stimulating phagocytosis
AssigneeUniversity of Pennsylvania
InventorsAlan D. Schreiber, Jong-Gu Park
Life of this patent
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Abstract
The present invention relates, in general, to methods of stimulating phagocytosis and thereby combating infection and/or modulating immune complex disease, in particular, to methods of modulating the number and type of Fc receptors present on cells that normally possess such receptors, including monocytes and macrophages, as well as on cells that normally do not possess Fc receptors, such as fibroblasts, and to compounds and compositions suitable for use in such methods.
Claims8
A method of treating an infection comprising:
- administering to a mammal in need of such treatment a DNA molecule encoding a single chain Fc receptor that comprises the cytoplasmic domain of FcγRIIA and that, upon production in a host cell, increases the phagocytic potential of said host cell,
- wherein said DNA molecule is present in a liposome or a viral vector and said administration is effected under conditions such that:
- i) said DNA molecule is expressed in macrophages, epithelial cells or fibroblasts of said mammal, ii) said Fc receptor is produced, and iii) the phagocytic potential of said macrophages, epithelial cells or fibroblasts of said mammal is thereby increased, and
- wherein said macrophages, epithelial cells or fibroblasts of said mammal phagocytose particles causing said infection so that said treatment is effected.
1 more element
Dependencies are inferred from the claim text.