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US 6,475,995 B1Granted
Oral delivery of nucleic acid vaccines by particulate complexes
AssigneeThe Johns Hopkins University
InventorsKrishnendu Roy, Shau-Ku Huang, Hugh Sampson, Kam W. Leong
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Abstract
Nanoparticle coacervates of nucleic acids and polycations serve as effective vaccines when administered orally. They can induce immunity to a variety of disease causing agents and raise a protective response to allergens.
Claims6
A method of eliciting an immune response in a mammal against an antigen, comprising:
- orally administering an immunogenic formulation comprising a solid nanoparticle of less than 5 μm comprising a coacervate of a polymeric polycation and a polyanion, wherein the polymeric polycation is selected from the group consisting of gelatin and chitosan, and wherein the polyanion consists of nucleic acids encoding an antigen, whereby the antigen is expressed and elicits an immune response in the mammal.
Dependencies are inferred from the claim text.