Methods of and compositions for potentiating the action of agents active on cell wall sites of the susceptible bacteria
AssigneePharmacy and Therapeutic Advisory Consultancy Pty LTD
InventorAllan Joseph McLean
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Abstract
The invention provides a method of potentiating the activity of antibacterial agents that act on bacterial cell walls, comprising the step of administering to a subject an antibacterial agent and an aminoglycoside to attain a peak concentration of at least 4 mg/l of aminoglycoside and thereafter maintaining the aminoglycoside at a concentration of up to 4 mg/l for at least 1 hour. Compositions comprising an antibacterial agent and an aminoglycoside for efficacious treatment of bacterial infection are also provided.
Claims12
An in vivo method of potentiating the activity of an antibacterial agent active on bacterial cell wall, comprising the steps of:
- (a) exposing said bacterial cell wall to an aminoglycoside in an amount effective to attain a peak concentration of 4 to 14 mg/l and thereafter maintaining the concentration substantially between 0.05 mg/l to 4 mg/l for at least 1 hour;
- and
- (b) exposing said bacterial cell wall to a single dose of said antibacterial agent wherein the concentration of the antibacterial agent is maintained at a concentration of at least 2 mg/l, while the concentration of the aminoglycoside declines.
Dependencies are inferred from the claim text.