Tall-1 receptor homologues
AssigneeNational Jewish Medical and Research Center
InventorHong-Bing Shu
Life of this patent
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Abstract
The amino acid and nucleic acid sequence of a protein expressed by monocytes and macrophages, called TALL-1, are disclosed. Homologues, mimetics and antibodies that bind to TALL-1 are disclosed. Also disclosed is the TALL-1 receptor, and homologues of such receptor. The invention includes methods for regulating the interaction between TALL-1 and its receptor and for identifying compounds capable of such regulation. The invention also includes methods for regulating B lymphocyte proliferation, activation, and/or survival.
Claims19
An isolated TALL-1 receptor homologue, wherein said homologue comprises an amino acid sequence that is:
- a. at least about 60% identical to SEQ ID NO:11;
- and,
- b. less than 100% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:11 and SEQ ID NO:17;
- wherein said TALL-1 receptor homologue binds to TALL-1.
A composition comprising:
- a. an isolated TALL-1 receptor homologue comprising an amino acid sequence selected that is:
- i. at least about 60% identical to SEQ ID NO:11;
- and
- ii. less than 100% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:11 and SEQ ID NO:17;
- wherein said TALL-1 receptor homologue binds to TALL-1;
- and,
- b. a pharmaceutically acceptable carrier.
An isolated TALL-1 receptor homologue, wherein said homologue comprises an amino acid sequence that is:
- a. at least about 60% identical to SEQ ID NO:11;
- and,
- b. less than 100% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:11 and SEQ ID NO:17;
- wherein said TALL-1 receptor homologue activates NF-κB in a cell expressing said homologue through a TRAF5, TRAF6, NIK, IKKα and IKKβ dependent pathway.
An isolated TALL-1 receptor homologue, wherein said homologue comprises an amino acid sequence that is:
- a. at least about 60% identical to SEQ ID NO:11;
- and,
- b. less than 100% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:11 and SEQ ID NO:17;
- wherein said TALL-1 receptor homologue costimulates B lymphocyte proliferation in a B lymphocyte expressing said homologue.
Dependencies are inferred from the claim text.