Water-soluble polypeptides having a high affinity for α and β interferons
AssigneeMedisup International N.V.
InventorsPierre Eid, Ion Gresser, Georges Lutfalla, Francois Meyer, Knud Erik Mogensen, Michael Tovey, Gilles Uze
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Abstract
Water-soluble polypeptides having high affinity for interferons α and β; DNA sequences and expression cells; a preparation method therefor; drugs; compositions containing same; and uses thereof as a diagnostic agent or for producing antibodies.
Claims31
An isolated polypeptide capable of binding to human α and β interferons, which polypeptide lacks a receptor transmembrane domain, wherein said polypeptide comprises an amino acid sequence selected from the group consisting of (a) SEQ ID NO:2, (b) SEQ ID NO:2 in which one amino acid is substituted or deleted, and (c) a fragment of (a) or (b) which is capable of binding to human α and β interferon.
An isolated polypeptide, consisting of the amino acid sequence of SEQ ID NO:
- 2.
A process for producing a polypeptide which lacks a transmembrane domain, wherein said polypeptide comprises the amino acid sequence of SEQ ID NO:2, comprising:
- culturing a host cell transformed with a nucleic acid encoding said polypeptide in a nutrient medium under conditions suitable for expressing the polypeptide;
- and
- recovering the expressed polypeptide from the cell culture.
Dependencies are inferred from the claim text.