Human telomerase catalytic subunit: diagnostic and therapeutic methods
AssigneesUniversity Technology Corporation, Geron Corporation
InventorsThomas R. Cech, Joachim Lingner, Toru Nakamura, Karen B. Chapman, Gregg B. Morin, Calvin B. Harley, William H. Andrews
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Abstract
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis, and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.
Claims8
A mammalian cell that contains a recombinant polynucleotide comprising a nucleic acid sequence that encodes a telomerase reverse transcriptase protein, variant, or fragment having telomerase catalytic activity when complexed with a telomerase RNA, wherein said recombinant polynucleotide hybridizes to a DNA having a sequence complementary to SEQ ID NO:
- 1 at 5° C. to 25° C. below Tm in aqueous solution at 1 M NaCl,
- wherein Tm is the melting temperature of a complementary polynucleotide hybridized to said DNA in aqueous solution at 1M NaCl, wherein the complementary polynucleotide is exactly complementary to SEQ ID NO:
- 1 and is the same length as the recombinant polynucleotide.
Dependencies are inferred from the claim text.