Trans-dominant suppressor genes for oligomeric proteins
AssigneeDana-Farber Cancer Institute, Inc.
InventorsMark K. Mercola, Prescott L. Deininger, Charles D. Stiles
Life of this patent
Estimating the term…
Abstract
The invention features two methods for making eucaryotic trans-dominant suppressor genes encoding polypeptide translation products capable of suppressing the activity of a growth factor that requires an oligomeric state for function, suppressor genes made by the methods, protein products of the suppressor genes, and methods for using these genes and protein products.
Claims10
A eucaryotic trans-dominant suppressor gene encoding a protein translation product which suppresses the activity of a growth factor that requires an oligomeric state for function, by forming an inactive oligomer with a wildtype subunit of said growth factor, said protein translation product being a mutant form of a wildtype subunit of said growth factor.
Dependencies are inferred from the claim text.