Method for preparing chiral esters
AssigneeSamsung Fine Chemicals Co., Ltd.
InventorsJai Wook Park, Mahn-Joo Kim, Jeong Hwan Koh, Hyun Min Jung
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Abstract
The present invention relates to a method for preparing a chiral ester and more particularly, the method for preparing an optically pure chiral ester from an alkenyl ester at a high yield by mixing and reacting: an alkenyl ester; a ruthenium complex to activate reduction reaction of said alkenyl ester and racemization; a lipase to acylate selectively one of enantiomers of said alkenyl ester; and a reducing agent to supply a hydride to said ruthenium complex. Said optically pure chiral ester of the present invention can be prepared by one-step synthesis from various types of alkenyl esters at a high yield.
Claims7
A process for preparing a chiral ester expressed in formula 100 by mixing and reacting:
- an alkenyl ester expressed by formula 6;
- a ruthenium complex selected from the group consisting of compounds 1 and 2 expressed in formulas 1 and 2 to activate reduction reaction of said alkenyl ester and racemization;
- a lipase to acylate selectively one of enantiomers of said alkenyl ester;
- and
- a reducing agent to supply a hydride to said ruthenium complex,
- wherein Y1, Y2, Y3, Y4, Y5, Y6, Y7, Y8, Y9, Y10, Y11, and Y12 are a hydrogen atom or C1-C5 alkyl group;
- X is Br, Cl or I;
- and Q is H, Br, Cl, or I;
- wherein Ph is phenyl;
- wherein R1, R2 and R3 are, independently, chosen from H, and optionally substituted alkyl, optionally substituted aryl, or optionally substituted cycloalkyl groups;
- and R1 and R2, R1 and R3, and R2 and R3 can be cyclized with each other, where said substituent of alkyl, aryl and cycloalkyl is a halogen atom or a cyano group.
Dependencies are inferred from the claim text.