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AssigneesHuman Genome Sciences, Inc., SmithKline Beecham Corporation
InventorsGregg A. Hastings, Mark D. Adams, Claire M. Fraser, Norman H. Lee, Ewen F. Kirkness, Judith A. Blake, Lisa M. Fitzgerald, Fred H. Drake, Maxine Gowan
Estimating the term…
Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.
An isolated polypeptide comprising human cathepsin-O.
An isolated polypeptide comprising mature human cathepsin O.
An isolated polypeptide comprising amino acids 1 to 214 of SEQ ID NO:2.
An isolated polypeptide produced by a transformed host cell from a polynucleotide comprising a first nucleic acid sequence at least 95% identical to a second nucleic acid sequence encoding amino acids 1 to 214 of SEQ ID NO:2, wherein the isolated polypeptide has protease activity.
An isolated polypeptide produced by a transformed host cell from a polynucleotide comprising a nucleic acid sequence encoding amino acids 1 to 214 of SEQ ID NO:2.
An isolated polypeptide produced by a host cell from a polynucleotide comprising a nucleic acid sequence encoding a mature human cathepsin O protein.
An isolated polypeptide produced by a transformed host cell from a polynucleotide comprising a nucleic acid sequence encoding the same mature polypeptide encoded by the human cDNA of ATCC Deposit No. 75671.
An isolated polypeptide comprising:
Dependencies are inferred from the claim text.