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US 6,475,740 B2Granted
Method for identifying a δ-eklf
AssigneeThe UAB Research Foundation
InventorsTim M. Townes, David Donze
Life of this patent
Estimating the term…
Abstract
The invention features δ-erythroid krüppel-like factors (δ-EKLFs), and methods of using nucleic acids encoding δ-EKLFs to increase δ-globin gene expression in a cell.
Claims2
A method for identifying a δ-EKLF polypeptide, said method comprising contacting a nucleic acid containing the sequence 5′-TGA AAC CCT-3′ or the sequence 5′-CTA ATG AAA-3′ with a candidate polypeptide that has been modified such that it differs from wild type β-EKLF by at least one amino acid and identifying said candidate polypeptide as a δ-EKLF polypeptide by its ability to bind to said nucleic acid.
Dependencies are inferred from the claim text.