Human BMP-2 promoter and method for exploring bone-related substance by using the same
AssigneeBiopharm Gesellschaft zur Biotechnologischen Entwicklung von Pharmaka GmbH
InventorTakeyuki Sugiura
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Abstract
The present invention provides a method for exploring low molecular weight compounds which regulate positively or negatively the expression of the human BMP-2 with reference to a reporter activity by using 5′ upstream region gene containing the human BMP-2 promoter and an animal cell introduced with a recombinant expression vector which has been connected to an appropriate reporter gene. The low molecular weight susbtances and their derivatives obtained by the present method have morphogenetic activity and inhibiting activity for bone and cartilage through the expression of human BMP-2 and are useful as preventive or therapeutic agents for bone and cartilage diseases.
Claims11
An isolated DNA whose nucleotide sequence comprises nucleotides 1 to 6728 shown in SEQ ID No:
- 1, or a fragment thereof which is effective as a human bone morphogenetic protein-2 promoter.
Dependencies are inferred from the claim text.