Genetic alterations associated with cancer

A method of screening for the presence of increased DNA copy number associated with cancer, the method comprising:

• contacting a nucleic acid sample comprising genomic DNA from a human patient with a probe which binds selectively to a target nucleic acid sequence at 3q26.3, wherein the target nucleic acid sequence is in a GLUT2 gene, and the probe is contacted with the sample under conditions in which the probe binds selectively with the target nucleic acid sequence to form a stable hybridization complex;
• and
• detecting the formation of a hybridization complex, wherein the amount of hybridization complex is increased relative to normal, thereby detecting the presence of DNA copy number changes associated with cancer.