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AssigneeThe United States of America as represented by the Secretary of Agriculture
InventorsRobin C. Anderson, David J. Nisbet, Larry H. Stanker
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The invention provides a method and compositions for controlling food borne enteric bacterial pathogens in animals. Populations of enteropathogenic bacteria may be substantially reduced or eliminated by treatment of animals with an effective amount of the compound Xm(ClO3)n, wherein X is a cationic moiety and m and n are independently selected from integers necessary to provide a net valency of 0. The compounds may be administered orally, providing a reduction in the populations of the enteropathogenic bacteria in the alimentary tract of the animal, or they may be applied externally onto the animal to reduce the populations of any such bacteria which may be present as contaminants on the surface of the animal. The method and compositions are particularly useful for the control of Salmonella species, enteropathogenic Escherichia coli, and Clostridia species.
A method for controlling bacterial enteropathogens in an animal comprising treating a meat-producing animal within about 96 hours prior to slaughter with a composition comprising Xm(ClO3)n in an amount effective to inhibit growth of enteropathogenic bacteria, wherein X is a cationic moiety and m and n are independently selected from integers necessary to provide a net valency of 0, which said composition is not toxic to non-pathogenic bacteria which lack respiratory nitrate reductases capable of reducing chlorate ion.
A method for controlling bacterial enteropathogens in an animal comprising treating said animal with a composition comprising Xm(ClO3)n in an amount effective to inhibit growth of enteropathogenic bacteria, wherein X is a cationic moiety and m and n are independently selected from integers necessary to provide a net valency of 0, which said composition is not toxic to non-pathogenic bacteria which lack respiratory nitrate reductases capable of reducing chlorate ion, and further wherein said treating comprises applying a composition of said Xm(ClO3)n onto said animal.
A method for controlling bacterial enteropathogens in an animal comprising treating said animal with a composition comprising Xm(ClO3)n in an amount effective to inhibit growth of enteropathogenic bacteria, wherein X is a cationic moiety and m and n are independently selected from integers necessary to provide a net valency of 0, which said composition is not toxic to non-pathogenic bacteria which lack respiratory nitrate reductases capable of reducing chlorate ion, and further comprising treating said animal with a nitrate in an amount effective to induce expression of respiratory nitrate reductase by said enteropathogenic bacteria.
A method for controlling bacterial enteropathogens in an animal comprising treating said animal with a composition comprising Xm(ClO3)n in an amount effective to inhibit growth of enteropathogenic bacteria, wherein X is a cationic moiety and m and n are independently selected from integers necessary to provide a net valency of 0, which said composition is not toxic to non-pathogenic bacteria which lack respiratory nitrate reductases capable of reducing chlorate ion, and further comprising treating said animal with a hydrogen donor.
Dependencies are inferred from the claim text.